Evaluation of anti-epileptic activity of leaf extracts of Punica granatum on experimental models of epilepsy in mice
Identifieur interne : 000229 ( Main/Exploration ); précédent : 000228; suivant : 000230Evaluation of anti-epileptic activity of leaf extracts of Punica granatum on experimental models of epilepsy in mice
Auteurs : Gollapalle L. Viswanatha [Inde] ; Marikunte V. Venkataranganna [Inde] ; Nunna Bheema Lingeswara Prasad [Inde] ; Godavarthi Ashok [Inde]Source :
- Journal of Intercultural Ethnopharmacology [ 2146-8397 ] ; 2016.
Abstract
This study was aimed to examine the anti-epileptic activity of leaf extracts of
Petroleum ether leaf extract of
In 6-Hz seizure test, the MLPG has alleviated 6-Hz-induced seizures significantly and dose dependently at doses 50, 100, 200, and 400 mg/kg. In contrast, PLPG and ALPG did not show any protection, only high dose of ALPG (400 and 800 mg/kg, p.o.) showed very slight inhibition. Based on these observations, only MLPG was tested in MES and PTZ models. Interestingly, the MLPG (50, 100, 200 and 400 mg/kg) has offered significant and dose-dependent protection against MES (
These findings suggest that MLPG possesses significant anticonvulsant property, and one of the possible mechanisms behind the anticonvulsant activity of MLPG may be through enhanced GABA levels in the brain.
Url:
DOI: 10.5455/jice.20160904102857
PubMed: 27757273
PubMed Central: 5061486
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Evaluation of anti-epileptic activity of leaf extracts of <italic>Punica granatum</italic> on experimental models of epilepsy in mice</title><author><name sortKey="Viswanatha, Gollapalle L" sort="Viswanatha, Gollapalle L" uniqKey="Viswanatha G" first="Gollapalle L." last="Viswanatha">Gollapalle L. Viswanatha</name><affiliation wicri:level="1"><nlm:aff id="aff1">Radiant Research Services Pvt. Ltd., Peenya Industrial Area, Bengaluru, Karnataka, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Radiant Research Services Pvt. Ltd., Peenya Industrial Area, Bengaluru, Karnataka</wicri:regionArea><wicri:noRegion>Karnataka</wicri:noRegion></affiliation></author><author><name sortKey="Venkataranganna, Marikunte V" sort="Venkataranganna, Marikunte V" uniqKey="Venkataranganna M" first="Marikunte V." last="Venkataranganna">Marikunte V. Venkataranganna</name><affiliation wicri:level="1"><nlm:aff id="aff2">Connexios Life Sciences Pvt. Ltd., Basavanagudi, Bengaluru, Karnataka, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Connexios Life Sciences Pvt. Ltd., Basavanagudi, Bengaluru, Karnataka</wicri:regionArea><wicri:noRegion>Karnataka</wicri:noRegion></affiliation></author><author><name sortKey="Prasad, Nunna Bheema Lingeswara" sort="Prasad, Nunna Bheema Lingeswara" uniqKey="Prasad N" first="Nunna Bheema Lingeswara" last="Prasad">Nunna Bheema Lingeswara Prasad</name><affiliation wicri:level="1"><nlm:aff id="aff3">Oil Technology Research Institute, JNT University Ananthapur, Ananthapuramu, Andhra Pradesh, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Oil Technology Research Institute, JNT University Ananthapur, Ananthapuramu, Andhra Pradesh</wicri:regionArea><wicri:noRegion>Andhra Pradesh</wicri:noRegion></affiliation></author><author><name sortKey="Ashok, Godavarthi" sort="Ashok, Godavarthi" uniqKey="Ashok G" first="Godavarthi" last="Ashok">Godavarthi Ashok</name><affiliation wicri:level="1"><nlm:aff id="aff1">Radiant Research Services Pvt. Ltd., Peenya Industrial Area, Bengaluru, Karnataka, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Radiant Research Services Pvt. Ltd., Peenya Industrial Area, Bengaluru, Karnataka</wicri:regionArea><wicri:noRegion>Karnataka</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27757273</idno><idno type="pmc">5061486</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061486</idno><idno type="RBID">PMC:5061486</idno><idno type="doi">10.5455/jice.20160904102857</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001056</idno><idno type="wicri:Area/Pmc/Curation">001055</idno><idno type="wicri:Area/Pmc/Checkpoint">000189</idno><idno type="wicri:Area/Ncbi/Merge">002206</idno><idno type="wicri:Area/Ncbi/Curation">002206</idno><idno type="wicri:Area/Ncbi/Checkpoint">002206</idno><idno type="wicri:Area/Main/Merge">000229</idno><idno type="wicri:Area/Main/Curation">000229</idno><idno type="wicri:Area/Main/Exploration">000229</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Evaluation of anti-epileptic activity of leaf extracts of <italic>Punica granatum</italic> on experimental models of epilepsy in mice</title><author><name sortKey="Viswanatha, Gollapalle L" sort="Viswanatha, Gollapalle L" uniqKey="Viswanatha G" first="Gollapalle L." last="Viswanatha">Gollapalle L. Viswanatha</name><affiliation wicri:level="1"><nlm:aff id="aff1">Radiant Research Services Pvt. Ltd., Peenya Industrial Area, Bengaluru, Karnataka, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Radiant Research Services Pvt. Ltd., Peenya Industrial Area, Bengaluru, Karnataka</wicri:regionArea><wicri:noRegion>Karnataka</wicri:noRegion></affiliation></author><author><name sortKey="Venkataranganna, Marikunte V" sort="Venkataranganna, Marikunte V" uniqKey="Venkataranganna M" first="Marikunte V." last="Venkataranganna">Marikunte V. Venkataranganna</name><affiliation wicri:level="1"><nlm:aff id="aff2">Connexios Life Sciences Pvt. Ltd., Basavanagudi, Bengaluru, Karnataka, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Connexios Life Sciences Pvt. Ltd., Basavanagudi, Bengaluru, Karnataka</wicri:regionArea><wicri:noRegion>Karnataka</wicri:noRegion></affiliation></author><author><name sortKey="Prasad, Nunna Bheema Lingeswara" sort="Prasad, Nunna Bheema Lingeswara" uniqKey="Prasad N" first="Nunna Bheema Lingeswara" last="Prasad">Nunna Bheema Lingeswara Prasad</name><affiliation wicri:level="1"><nlm:aff id="aff3">Oil Technology Research Institute, JNT University Ananthapur, Ananthapuramu, Andhra Pradesh, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Oil Technology Research Institute, JNT University Ananthapur, Ananthapuramu, Andhra Pradesh</wicri:regionArea><wicri:noRegion>Andhra Pradesh</wicri:noRegion></affiliation></author><author><name sortKey="Ashok, Godavarthi" sort="Ashok, Godavarthi" uniqKey="Ashok G" first="Godavarthi" last="Ashok">Godavarthi Ashok</name><affiliation wicri:level="1"><nlm:aff id="aff1">Radiant Research Services Pvt. Ltd., Peenya Industrial Area, Bengaluru, Karnataka, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Radiant Research Services Pvt. Ltd., Peenya Industrial Area, Bengaluru, Karnataka</wicri:regionArea><wicri:noRegion>Karnataka</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Intercultural Ethnopharmacology</title><idno type="eISSN">2146-8397</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Objectives:</title><p>This study was aimed to examine the anti-epileptic activity of leaf extracts of <italic>Punica granatum</italic> in experimental models of epilepsy in Swiss albino mice.</p></sec><sec id="st2"><title>Materials and Methods:</title><p>Petroleum ether leaf extract of <italic>P. granatum</italic> (PLPG), methanolic LPG (MLPG), and aqueous LPG (ALPG) extracts of <italic>P. granatum</italic> leaves was initially evaluated against 6-Hz-induced seizure model; the potent extract was further evaluated against maximal electroshock (MES) and pentylenetetrazole (PTZ)-induced convulsions. Further, the potent extract was evaluated for its influence on Gamma amino butyric acid (GABA) levels in brain, to explore the possible mechanism of action. In addition, the potent extract was subjected to actophotometer test to assess its possible locomotor activity deficit inducing action.</p></sec><sec id="st3"><title>Results:</title><p>In 6-Hz seizure test, the MLPG has alleviated 6-Hz-induced seizures significantly and dose dependently at doses 50, 100, 200, and 400 mg/kg. In contrast, PLPG and ALPG did not show any protection, only high dose of ALPG (400 and 800 mg/kg, p.o.) showed very slight inhibition. Based on these observations, only MLPG was tested in MES and PTZ models. Interestingly, the MLPG (50, 100, 200 and 400 mg/kg) has offered significant and dose-dependent protection against MES (<italic>P</italic> < 0.01) and PTZ-induced (<italic>P</italic> < 0.01) seizures in mice. Further, MLPG showed a significant increase in brain GABA levels (<italic>P</italic> < 0.01) compared to control and showed insignificant change in locomotor activity in all tested doses (100, 200 and 400 mg/kg). Interestingly, higher dose of MLPG (400 mg/kg, p.o.) and Diazepam (5 mg/mg, p.o.) have completely abolished the convulsions in all the anticonvulsant tests.</p></sec><sec id="st4"><title>Conclusion:</title><p>These findings suggest that MLPG possesses significant anticonvulsant property, and one of the possible mechanisms behind the anticonvulsant activity of MLPG may be through enhanced GABA levels in the brain.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Trinka, E" uniqKey="Trinka E">E Trinka</name></author><author><name sortKey="Cock, H" uniqKey="Cock H">H Cock</name></author><author><name sortKey="Hesdorffer, D" uniqKey="Hesdorffer D">D Hesdorffer</name></author><author><name sortKey="Rossetti, A" uniqKey="Rossetti A">A Rossetti</name></author><author><name sortKey="Scheffer, Ie" uniqKey="Scheffer I">IE Scheffer</name></author><author><name sortKey="Shinnar, S" uniqKey="Shinnar S">S 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Kostopoulos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, Rq" uniqKey="Huang R">RQ Huang</name></author><author><name sortKey="Bell Horner, Cl" uniqKey="Bell Horner C">CL Bell-Horner</name></author><author><name sortKey="Dibas, Mi" uniqKey="Dibas M">MI Dibas</name></author><author><name sortKey="Covey, Df" uniqKey="Covey D">DF Covey</name></author><author><name sortKey="Drewe, Ja" uniqKey="Drewe J">JA Drewe</name></author><author><name sortKey="Dillon, Gh" uniqKey="Dillon G">GH Dillon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, Hl" uniqKey="Zhu H">HL Zhu</name></author><author><name sortKey="Wan, Jb" uniqKey="Wan J">JB Wan</name></author><author><name sortKey="Wang, Yt" uniqKey="Wang Y">YT Wang</name></author><author><name sortKey="Li, Bc" uniqKey="Li B">BC Li</name></author><author><name sortKey="Xiang, C" uniqKey="Xiang C">C Xiang</name></author><author><name sortKey="He, J" uniqKey="He J">J He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jain, V" uniqKey="Jain V">V Jain</name></author><author><name sortKey="Viswanatha, Gl" uniqKey="Viswanatha G">GL Viswanatha</name></author><author><name sortKey="Manohar, D" uniqKey="Manohar D">D Manohar</name></author><author><name sortKey="Shivaprasad, Hn" uniqKey="Shivaprasad H">HN Shivaprasad</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Viswanatha, Gollapalle L" sort="Viswanatha, Gollapalle L" uniqKey="Viswanatha G" first="Gollapalle L." last="Viswanatha">Gollapalle L. Viswanatha</name></noRegion><name sortKey="Ashok, Godavarthi" sort="Ashok, Godavarthi" uniqKey="Ashok G" first="Godavarthi" last="Ashok">Godavarthi Ashok</name><name sortKey="Prasad, Nunna Bheema Lingeswara" sort="Prasad, Nunna Bheema Lingeswara" uniqKey="Prasad N" first="Nunna Bheema Lingeswara" last="Prasad">Nunna Bheema Lingeswara Prasad</name><name sortKey="Venkataranganna, Marikunte V" sort="Venkataranganna, Marikunte V" uniqKey="Venkataranganna M" first="Marikunte V." last="Venkataranganna">Marikunte V. Venkataranganna</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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